For this purpose, we initially generated a large number of features that were defined as the presence or absence of TFs in different promoter regions around TSSs. We assessed the transcriptional significance of cell line-specific features using regression analysis of ChIP-Seq datasets from the GTRD database and transcriptional start site (TSS) activities from the FANTOM5 expression atlas. Over the past decade, ChIP-Seq has become the most common experimental technology studying genome-wide interactions between TFs and DNA. ![]() Regulation of transcription is a complex process carried out by transcription factors (TFs) and auxiliary proteins. ![]() Creating a complete picture of the regulation of transcription seems to be an urgent task of modern biology.
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